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Coronavirus (Covid19) application
According to a group of scientists from the University of Basel (André Fischer, Manuel Selner, Santos Nerandjan, Markus A. Lille, and Martin Smiesko), taxifolin is one of the 11 most powerful natural compounds in the world, and is the only one directly available to consumers with the potential to inhibit Covid-19 activity in human cells.
To find new inhibitors, scientists from the University of Basel (André Fischer, Manuel Selner, Santos Nerandjan, Markus A. Lille, and Martin Smiesko) conducted a computer screening of a database of over 687 million compounds. After the analysis, a list of 11 compounds with improved free energy binding to the target protease was published. Also, a strong binder with comparable properties from the library of natural compounds was identified.
"The Siberian larch (Larix sibirica) is known to produce taxifolin offering a natural resource for its extraction. Furthermore, food preparations containing taxifolin are readily available from pharmacies and other companies allowing direct and fast access to the potential antiviral. Remarkably, taxifolin underwent seven hydrogen bonds which represent the highest count in our selection of compounds. Since hydrogen bonds are a key determinant for drug specificity, taxifolin might offer a naturally occurring alternative to the proposed inhibitors CP-1 to CP-11."
A group of scientists from the Institute of Theoretical and Experimental Biophysics analyzed literature data and the experience of medical practitioners and published their observations in the journal European Review for Medical and Pharmacological Sciences.
Considering the literature data and the experience of practicing doctors, one can assume that the COVID-19 infection is accompanied, particularly in severe cases, by pulmonary oxidative stress, which causes profound structural changes in the lung tissue.
Due to the coronavirus-induced degradation of Hb molecules, a decrease in the pool of redox-active erythrocytes and the accumulation of a large amount of free iron ions occur; in all organs and tissues, hypox- ia and oxidative stress may develop. To prevent these events in COVID-19 patients, we propose to use the pyrimidine nucleoside uridine and the antioxidant dihydroquercetin, which are promising in the treatment of hypoxia-induced injury of the lungs and respiratory diseases. They may be useful for the treatment of COVID-19 patients and the restoration of their body after such a serious illness."